Had a customer who was having issues opening Office attachments from Outlook. EMET was popping up and preventing Excel and Word from opening attachments in Outlook.

I found this article which got me started.

https://social.technet.microsoft.com/Forums/office/en-US/deeb260d-96c5-4cb4-80a0-f5242d33095b/emet-55-simexecflow-blocking-excel-amp-other-office-opening?forum=emet

This didn’t fix the issue because Excel and Word were still blocked by EMET.  This also messed up the Office 2013 install, so I ran a repair on Office 2013 from Add and Remove Programs. When Excel opened up I had to re-activate the Office programs. I got this repaired.

I removed EMET and re-installed the latest EMET 5.5. This still didn’t resolve the issue. I found this this next link that lead me down a good path.

https://forums.malwarebytes.com/topic/144762-emet-simexecflow-problem-now-appears-fix-on-my-system/

I removed MalwareBytes, restarted the machine, and everything was working now.

I imported the three .XML files mentioned in the link above as well.

Let us know if this helped you…